Tuesday's match was the latest masterclass from the South American trio, known in Spain as 'MSN', whose goals have put Barca on the brink of repeating 2009's treble of Champions League and Spanish league and Cup triumphs, the only time a La Liga club have achieved the feat.
The goal machines of Bayern Munich, Chelsea and Shakhtar Donetsk cranked into top gear on Tuesday as the Champions League captivated its continental audience with a record 40 goals in one eight-game night.
News of all that's transpired on and off the football field
Real Madrid set up a King's Cup semi-final against holders Atletico Madrid or Athletic Bilbao when they beat Espanyol 1-0 in their quarter-final, second leg on Tuesday for a 2-0 aggregate success.
'Our plan is to put the best foot forward for the upcoming tournament and play good matches'
Real Madrid lifted the FIFA Club World Cup for a record fourth time on Saturday after thrashing local side Al Ain 4-1 in the final in Abu Dhabi with the help of impressive distance strikes in either half from midfielders Luka Modric and Marcos Llorente.
Barcelona's 2-1 loss at Ajax Amsterdam in the Champions League last week was down to a lack of intensity while Sunday's 1-0 reverse at Athletic Bilbao in La Liga exposed their relative physical frailty.
News of all that's transpired on and off the football field
Lionel Messi, Luis Suarez and Neymar combined to devastating effect as Barcelona swatted Celtic aside 7-0 at the Nou Camp to lay down a marker in Champions League Group C on Tuesday.
A summary of all the Champions League matches played across Europe on Tuesday
ManchesterCity's hopes of regaining the Premier League title suffered a potentially grievous blow on Saturday as they were held to a goalless draw by struggling NorwichCity at Carrow Road.
Atletico Madrid have a chance to pile more King's Cup misery on neighbours Real after eliminating Athletic Bilbao on Wednesday to set up a last-four clash against the bitter city rivals they beat in last year's final.
News of all that's transpired on and off the football field
'Our defence system starts with our first four and that's why we have a solid defence. People look to Brazil and always try to find players who score or dribble but we have many other qualities. With our goalkeeper and defenders, we have a solid defence' 'It's pretty exciting for us and we are looking to do something great here'
News of all that's transpired on and off the football field
News of all that's transpired on and off the football field
News of all that's transpired on and off the football field on Saturday
Manchester City swept aside second-tier Cardiff City 2-0 with first-half goals from Kevin De Bruyne and Raheem Sterling on Sunday to reach the FA Cup fifth round in their quest to win an unprecedented four trophies this season.
Images from the UEFA Champions League matches played across Europe on Wednesday
Check out the top footballers of the weekend...
Robert Lewandowski scored a brilliant free kick to give Bayern Munich a 1-0 win over Atletico Madrid in their last Champions League Group D outing on Tuesday, ending the 100 percent record of their opponents. The Poland international curled the ball over the wall and into the corner of the net in the 28th minute but the goal had no impact on the final standings with Atletico guaranteed top spot and Bayern in second place.
Wales will move higher than their richer rivals and neighbours England when the new FIFA rankings are announced after Euro 2016, the first sign for what, many predict, will be a bright future after they made history at the tournament. Playing in their first finals since 1958, the Welsh reached the last four of a major tournament for the first time and are expected to move up close to the top 10 countries in the world rankings.
La Liga leaders Real Madrid dropped points at home for only the second time this season.
Croatia, helped by a mistake by veteran goalkeeper Gianluigi Buffon, held Italy to a 1-1 away draw on Sunday, but their evening was ruined by their fans who twice interrupted play by throwing flares onto the pitch.
Following Bayern Munich's brilliant 7-4 (on aggregate) win over FC Porto in the quarter-finals of the Champions League, here's a look at a few memorable come-from-behind victories in Europe's premier football competition.
News of all that's transpired on and off the football field
Lionel Messi-inspired Barcelona overwhelmed Manchester City as Ivan Rakitic's strike secured a 1-0 win.
Real Madrid winger Gareth Bale answered his critics in emphatic style.
Cristiano Ronaldo ensured Atletico Madrid fans will have bitter memories of the last local derby at the Vicente Calderon stadium by scoring a hat-trick in a 3-0 win for La Liga leaders Real Madrid on Saturday. Ronaldo's deflected free kick put Real in charge in the 23rd minute in the first meeting of the teams since the Champions League final in May. The prolific Portuguese killed off Atletico's resistance by winning and converting a penalty in the 71st minute and capped a harrowing night for the home side by tapping in the third in the 77th.
Barcelona's Luis Suarez netted twice for a 2-1 win over 10-man Atletico Madrid in their Champions League quarter-final, first leg on Tuesday after the visitors' Fernando Torres opened the scoring and was later sent off.
Barcelona look well set to wrap up the La Liga title.
A summary of Tuesday night's matches in the UEFA champions League.
Holders Spain suffered their first defeat in qualifying for a major tournament in eight years when Miroslav Stoch nodded a late goal to earn Slovakia a shock 2-1 victory in Euro 2016 Group C on Thursday.
News of all that's transpired on and off the football field
Bringing you all the news from the summer transfer window and other snippets from the soccer world...
On-field achievements often jostled for space with off-field drama as Indian hockey endured a rollercoaster year during which the players scripted historical feats but coach Paul van Ass' acrimonious ouster and Gurbaj Singh's suspension created its share of storm.
Anyone who has watched the Argentine in recent years knows he can do things with a football that seem to defy the laws of physics and he does not fit into the mould of a traditional striker.
A summary of sports events and sports persons, who made news on Tuesday
Key head-to-head battles in Saturday's "Clasico" between Real Madrid and Barcelona at the Bernabeu stadium (1600 GMT)
News of all that's transpired on and off the football field.